Leucine-rich repeat-containing protein 49 (LRRC49)
Homo sapiens — UniProt Q8IUZ0
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 49 (LRRC49) is a protein from Homo sapiens identified by UniProt accession Q8IUZ0, 686 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q8IUZ0; gene symbol LRRC49.
- Organism: Homo sapiens.
- Length: 686 amino acids.
- Top disease associations (Open Targets): appendicular lean mass, protein measurement and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 49 |
|---|---|
| UniProt accession | Q8IUZ0 |
| Gene | LRRC49 |
| Organism | Homo sapiens |
| Length | 686 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.33
- protein measurement · score 0.28
- FEV/FVC ratio · score 0.26
- metabolite measurement · score 0.21
- brain volume measurement · score 0.21
- cortical thickness · score 0.20
- glucuronate measurement · score 0.13
- eosinophil count · score 0.05
- cortical surface area measurement · score 0.05
- brain measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUZ0-F1 | alphafold | PREDICTED | 75.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUZ0.
Amino-acid sequence (686 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC49?
The strongest Open Targets associations for LRRC49 are appendicular lean mass, protein measurement, FEV/FVC ratio, metabolite measurement and brain volume measurement.
How long is the LRRC49 protein?
The Homo sapiens LRRC49 protein (UniProt Q8IUZ0) is 686 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUZ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUZ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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