5-phosphohydroxy-L-lysine phospho-lyase (PHYKPL)
Homo sapiens — UniProt Q8IUZ5
Data last refreshed: (UniProt release unknown)
Key facts
5-phosphohydroxy-L-lysine phospho-lyase (PHYKPL) is a protein from Homo sapiens identified by UniProt accession Q8IUZ5, 450 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q8IUZ5; gene symbol PHYKPL.
- Organism: Homo sapiens.
- Length: 450 amino acids.
- Top disease associations (Open Targets): phosphohydroxylysinuria, mean corpuscular volume and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 5-phosphohydroxy-L-lysine phospho-lyase |
|---|---|
| UniProt accession | Q8IUZ5 |
| Gene | PHYKPL |
| Organism | Homo sapiens |
| Length | 450 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- phosphohydroxylysinuria · score 0.57
- mean corpuscular volume · score 0.31
- breast adenocarcinoma · score 0.22
- mean corpuscular hemoglobin concentration · score 0.22
- reticulocyte measurement · score 0.20
- lung adenocarcinoma · score 0.18
- mean corpuscular hemoglobin · score 0.18
- reticulocyte count · score 0.17
- Immature Reticulocyte Fraction Measurement · score 0.15
- gut microbiome measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUZ5-F1 | alphafold | PREDICTED | 96.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUZ5.
Amino-acid sequence (450 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHYKPL?
The strongest Open Targets associations for PHYKPL are phosphohydroxylysinuria, mean corpuscular volume, breast adenocarcinoma, mean corpuscular hemoglobin concentration and reticulocyte measurement.
How long is the PHYKPL protein?
The Homo sapiens PHYKPL protein (UniProt Q8IUZ5) is 450 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUZ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUZ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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