Prolyl 3-hydroxylase 3 (P3H3)
Homo sapiens — UniProt Q8IVL6
Data last refreshed: (UniProt release unknown)
Key facts
Prolyl 3-hydroxylase 3 (P3H3) is a protein from Homo sapiens identified by UniProt accession Q8IVL6, 736 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q8IVL6; gene symbol P3H3.
- Organism: Homo sapiens.
- Length: 736 amino acids.
- Top disease associations (Open Targets): osteoarthritis, knee, Adult-onset autosomal recessive sideroblastic anemia and microcytic anemia with liver iron overload.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prolyl 3-hydroxylase 3 |
|---|---|
| UniProt accession | Q8IVL6 |
| Gene | P3H3 |
| Organism | Homo sapiens |
| Length | 736 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- osteoarthritis, knee · score 0.09
- Adult-onset autosomal recessive sideroblastic anemia · score 0.06
- microcytic anemia with liver iron overload · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- dehydrated hereditary stomatocytosis · score 0.05
- hemoglobin D disease · score 0.05
- familial pseudohyperkalemia · score 0.05
- hemochromatosis type 5 · score 0.04
- FTH1-related iron overload · score 0.04
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IVL6-F1 | alphafold | PREDICTED | 81.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IVL6.
Amino-acid sequence (736 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with P3H3?
The strongest Open Targets associations for P3H3 are osteoarthritis, knee, Adult-onset autosomal recessive sideroblastic anemia, microcytic anemia with liver iron overload, hemoglobin E-beta-thalassemia syndrome and dehydrated hereditary stomatocytosis.
How long is the P3H3 protein?
The Homo sapiens P3H3 protein (UniProt Q8IVL6) is 736 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IVL6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IVL6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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