V-set and transmembrane domain-containing protein 4…

About V-set and transmembrane domain-containing protein 4

V-set and transmembrane domain-containing protein 4 (VSTM4) is a protein from Homo sapiens identified by UniProt accession Q8IW00, 320 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	V-set and transmembrane domain-containing protein 4
UniProt accession	Q8IW00
Gene	VSTM4
Organism	Homo sapiens
Length	320 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.48
monocyte count · score 0.48
platelet count · score 0.47
lymphocyte count · score 0.47
platelet crit · score 0.43
mean corpuscular hemoglobin concentration · score 0.42
leukocyte count · score 0.40
mean corpuscular volume · score 0.39
reticulocyte count · score 0.39
brain measurement · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IW00-F1	alphafold	PREDICTED	74.87	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IW00.

Amino-acid sequence (320 residues)

MRLLALAAAA LLARAPAPEV CAALNVTVSP GPVVDYLEGE NATLLCHVSQ KRRKDSLLAV RWFFAHSFDS QEALMVKMTK LRVVQYYGNF SRSAKRRRLR LLEEQRGALY RLSVLTLQPS DQGHYVCRVQ EISRHRNKWT AWSNGSSATE MRVISLKASE ESSFEKTKET WAFFEDLYVY AVLVCCVGIL SILLFMLVIV WQSVFNKRKS RVRHYLVKCP QNSSGETVTS VTSLAPLQPK KGKRQKEKPD IPPAVPAKAP IAPTFHKPKL LKPQRKVTLP KIAEENLTYA ELELIKPHRA AKGAPTSTVY AQILFEENKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

V-set and transmembrane domain-containing protein 4 (VSTM4)