Seven in absentia homolog 3 (SIAH3)

About Seven in absentia homolog 3

Seven in absentia homolog 3 (SIAH3) is a protein from Homo sapiens identified by UniProt accession Q8IW03, 269 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Seven in absentia homolog 3
UniProt accession	Q8IW03
Gene	SIAH3
Organism	Homo sapiens
Length	269 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

ventricular enlargement measurement · score 0.33
cortical surface area measurement · score 0.24
metabolite measurement · score 0.23
body height · score 0.17
blood protein measurement · score 0.07
type 2 diabetes mellitus · score 0.04
pancreatic adenocarcinoma · score 0.04
breast carcinoma · score 0.04
glucose measurement · score 0.04
chronic kidney disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IW03-F1	alphafold	PREDICTED	73.06	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IW03.

Amino-acid sequence (269 residues)

MLFFTQCFGA VLDLIHLRFQ HYKAKRVFSA AGQLVCVVNP THNLKYVSSR RAVTQSAPEQ GSFHPHHLSH HHCHHRHHHH LRHHAHPHHL HHQEAGLHAN PVTPCLCMCP LFSCQWEGRL EVVVPHLRQI HRVDILQGAE IVFLATDMHL PAPADWIIMH SCLGHHFLLV LRKQERHEGH PQFFATMMLI GTPTQADCFT YRLELNRNHR RLKWEATPRS VLECVDSVIT DGDCLVLNTS LAQLFSDNGS LAIGIAITAT EVLPSEAEM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards