Aprataxin and PNK-like factor (APLF)
Homo sapiens — UniProt Q8IW19
Data last refreshed: (UniProt release unknown)
Key facts
Aprataxin and PNK-like factor (APLF) is a protein from Homo sapiens identified by UniProt accession Q8IW19, 511 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q8IW19; gene symbol APLF.
- Organism: Homo sapiens.
- Length: 511 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, monocyte count and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Aprataxin and PNK-like factor |
|---|---|
| UniProt accession | Q8IW19 |
| Gene | APLF |
| Organism | Homo sapiens |
| Length | 511 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.39
- monocyte count · score 0.19
- leukocyte count · score 0.18
- mean platelet volume · score 0.17
- multiple sclerosis · score 0.13
- glioblastoma multiforme · score 0.07
- platelet count · score 0.07
- basophil count · score 0.06
- myeloid white cell count · score 0.05
- platelet component distribution width · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IW19-F1 | alphafold | PREDICTED | 61.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IW19.
Amino-acid sequence (511 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with APLF?
The strongest Open Targets associations for APLF are Red cell distribution width, monocyte count, leukocyte count, mean platelet volume and multiple sclerosis.
How long is the APLF protein?
The Homo sapiens APLF protein (UniProt Q8IW19) is 511 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IW19 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IW19 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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