Serpin A12 (SERPINA12)

About Serpin A12

Serpin A12 (SERPINA12) is a protein from Homo sapiens identified by UniProt accession Q8IW75, 414 residues long. MolForge cross-references it against 0 known binders and 229 disease associations.

Target properties

Protein name	Serpin A12
UniProt accession	Q8IW75
Gene	SERPINA12
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (229)

Diseases linked to this target (Open Targets).

hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.51
blood protein measurement · score 0.41
childhood trauma measurement · score 0.27
smoking behaviour measurement · score 0.27
vitamin D measurement · score 0.15
metabolic syndrome · score 0.11
type 2 diabetes mellitus · score 0.11
kallistatin measurement · score 0.10
gestational diabetes · score 0.10
hepatocellular carcinoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IW75-F1	alphafold	PREDICTED	88.46	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IW75.

Amino-acid sequence (414 residues)

MNPTLGLAIF LAVLLTVKGL LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards