Rho guanine nucleotide exchange factor 19 (ARHGEF19)

About Rho guanine nucleotide exchange factor 19

Rho guanine nucleotide exchange factor 19 (ARHGEF19) is a protein from Homo sapiens identified by UniProt accession Q8IW93, 802 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Rho guanine nucleotide exchange factor 19
UniProt accession	Q8IW93
Gene	ARHGEF19
Organism	Homo sapiens
Length	802 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.34
aspartate aminotransferase measurement · score 0.31
serum alanine aminotransferase measurement · score 0.31
sex hormone-binding globulin measurement · score 0.31
balding measurement · score 0.31
apolipoprotein B measurement · score 0.28
serum albumin measurement · score 0.28
non-alcoholic fatty liver disease · score 0.27
neutrophil percentage of leukocytes · score 0.25
lymphocyte percentage of leukocytes · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IW93-F1	alphafold	PREDICTED	64.66	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IW93.

Amino-acid sequence (802 residues)

MDCGPPATLQ PHLTGPPGTA HHPVAVCQQE SLSFAELPAL KPPSPVCLDL FPVAPEELRA PGSRWSLGTP APLQGLLWPL SPGGSDTEIT SGGMRPSRAG SWPHCPGAQP PALEGPWSPR HTQPQRRASH GSEKKSAWRK MRVYQREEVP GCPEAHAVFL EPGQVVQEQA LSTEEPRVEL SGSTRVSLEG PERRRFSASE LMTRLHSSLR LGRNSAARAL ISGSGTGAAR EGKASGMEAR SVEMSGDRVS RPAPGDSREG DWSEPRLDTQ EEPPLGSRST NERRQSRFLL NSVLYQEYSD VASARELRRQ QREEEGPGDE AEGAEEGPGP PRANLSPSSS FRAQRSARGS TFSLWQDIPD VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG HFLGSAELSE CLGAQDKQWL FSKLPEVKST SERFLQDLEQ RLEADVLRFS VCDVVLDHCP AFRRVYLPYV TNQAYQERTY QRLLLENPRF PGILARLEES PVCQRLPLTS FLILPFQRIT RLKMLVENIL KRTAQGSEDE DMATKAFNAL KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHAKMAE LQVRDLSLKL QGIPGHVFLL QLLHGQHMKH QFLLRARTES EKQRWISALC PSSPQEDKEV ISEGEDCPQV QCVRTYKALH PDELTLEKTD ILSVRTWTSD GWLEGVRLAD GEKGWVPQAY VEEISSLSAR LRNLRENKRV TSATSKLGEA PV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards