WD repeat-containing protein 75 (WDR75)
Homo sapiens — UniProt Q8IWA0
Data last refreshed: (UniProt release unknown)
Key facts
WD repeat-containing protein 75 (WDR75) is a protein from Homo sapiens identified by UniProt accession Q8IWA0, 830 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8IWA0; gene symbol WDR75.
- Organism: Homo sapiens.
- Length: 830 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroimaging measurement and cortical thickness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WD repeat-containing protein 75 |
|---|---|
| UniProt accession | Q8IWA0 |
| Gene | WDR75 |
| Organism | Homo sapiens |
| Length | 830 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- neuroimaging measurement · score 0.23
- cortical thickness · score 0.21
- lysosomal storage disease · score 0.20
- erythrocyte count · score 0.20
- vital capacity · score 0.20
- iron biomarker measurement · score 0.19
- blood protein measurement · score 0.18
- brain measurement · score 0.17
- ferritin measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWA0-F1 | alphafold | PREDICTED | 80.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWA0.
Amino-acid sequence (830 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WDR75?
The strongest Open Targets associations for WDR75 are neurodegenerative disease, neuroimaging measurement, cortical thickness, lysosomal storage disease and erythrocyte count.
How long is the WDR75 protein?
The Homo sapiens WDR75 protein (UniProt Q8IWA0) is 830 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWA0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWA0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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