Pleckstrin homology domain-containing family M member 2 (PLEKHM2)
Homo sapiens — UniProt Q8IWE5
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family M member 2 (PLEKHM2) is a protein from Homo sapiens identified by UniProt accession Q8IWE5, 1019 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q8IWE5; gene symbol PLEKHM2.
- Organism: Homo sapiens.
- Length: 1019 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, autosomal recessive dilated cardiomyopathy and pulse pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family M member 2 |
|---|---|
| UniProt accession | Q8IWE5 |
| Gene | PLEKHM2 |
| Organism | Homo sapiens |
| Length | 1019 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.20
- autosomal recessive dilated cardiomyopathy · score 0.19
- pulse pressure measurement · score 0.16
- type 2 diabetes mellitus · score 0.11
- brain measurement · score 0.09
- chronotype measurement · score 0.08
- cardiomyopathy · score 0.07
- metabolite measurement · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- X-linked severe congenital neutropenia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWE5-F1 | alphafold | PREDICTED | 64.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWE5.
Amino-acid sequence (1019 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHM2?
The strongest Open Targets associations for PLEKHM2 are systolic blood pressure, autosomal recessive dilated cardiomyopathy, pulse pressure measurement, type 2 diabetes mellitus and brain measurement.
How long is the PLEKHM2 protein?
The Homo sapiens PLEKHM2 protein (UniProt Q8IWE5) is 1019 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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