Dynein axonemal intermediate chain 3 (DNAI3)
Homo sapiens — UniProt Q8IWG1
Data last refreshed: (UniProt release unknown)
Key facts
Dynein axonemal intermediate chain 3 (DNAI3) is a protein from Homo sapiens identified by UniProt accession Q8IWG1, 891 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q8IWG1; gene symbol DNAI3.
- Organism: Homo sapiens.
- Length: 891 amino acids.
- Top disease associations (Open Targets): hair color, hair colour measurement and occipital encephalocele.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein axonemal intermediate chain 3 |
|---|---|
| UniProt accession | Q8IWG1 |
| Gene | DNAI3 |
| Organism | Homo sapiens |
| Length | 891 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- hair color · score 0.33
- hair colour measurement · score 0.26
- occipital encephalocele · score 0.26
- PHF-tau measurement · score 0.04
- male infertility · score 0.04
- central nervous system cancer · score 0.03
- sitting height measurement · score 0.03
- ependymoma · score 0.02
- squamous cell carcinoma · score 0.02
- visceral Leishmaniasis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWG1-F1 | alphafold | PREDICTED | 76.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWG1.
Amino-acid sequence (891 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAI3?
The strongest Open Targets associations for DNAI3 are hair color, hair colour measurement, occipital encephalocele, PHF-tau measurement and male infertility.
How long is the DNAI3 protein?
The Homo sapiens DNAI3 protein (UniProt Q8IWG1) is 891 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWG1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWG1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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