GRIP and coiled-coil domain-containing protein 2 (GCC2)
Homo sapiens — UniProt Q8IWJ2
Data last refreshed: (UniProt release unknown)
Key facts
GRIP and coiled-coil domain-containing protein 2 (GCC2) is a protein from Homo sapiens identified by UniProt accession Q8IWJ2, 1684 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8IWJ2; gene symbol GCC2.
- Organism: Homo sapiens.
- Length: 1684 amino acids.
- Top disease associations (Open Targets): cancer, low density lipoprotein cholesterol measurement and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GRIP and coiled-coil domain-containing protein 2 |
|---|---|
| UniProt accession | Q8IWJ2 |
| Gene | GCC2 |
| Organism | Homo sapiens |
| Length | 1684 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- cancer · score 0.47
- low density lipoprotein cholesterol measurement · score 0.36
- alkaline phosphatase measurement · score 0.34
- mean platelet volume · score 0.33
- platelet count · score 0.25
- body height · score 0.24
- neurofibrillary tangles measurement · score 0.24
- femoral neck bone mineral density · score 0.22
- Hirsutism · score 0.15
- platelet component distribution width · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWJ2-F1 | alphafold | PREDICTED | 71.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWJ2.
Amino-acid sequence (1684 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GCC2?
The strongest Open Targets associations for GCC2 are cancer, low density lipoprotein cholesterol measurement, alkaline phosphatase measurement, mean platelet volume and platelet count.
How long is the GCC2 protein?
The Homo sapiens GCC2 protein (UniProt Q8IWJ2) is 1684 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWJ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWJ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.