Adhesion G protein-coupled receptor A3 (ADGRA3)
Homo sapiens — UniProt Q8IWK6
Data last refreshed: (UniProt release unknown)
Key facts
Adhesion G protein-coupled receptor A3 (ADGRA3) is a protein from Homo sapiens identified by UniProt accession Q8IWK6, 1321 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q8IWK6; gene symbol ADGRA3.
- Organism: Homo sapiens.
- Length: 1321 amino acids.
- Target class: GPCR.
- Top disease associations (Open Targets): adolescent idiopathic scoliosis, autosomal recessive retinitis pigmentosa and retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adhesion G protein-coupled receptor A3 |
|---|---|
| UniProt accession | Q8IWK6 |
| Gene | ADGRA3 |
| Organism | Homo sapiens |
| Length | 1321 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | GPCR (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.41
- autosomal recessive retinitis pigmentosa · score 0.33
- retinitis pigmentosa · score 0.26
- PHF-tau measurement · score 0.23
- urinary metabolite measurement · score 0.23
- urate measurement · score 0.22
- serum metabolite measurement · score 0.19
- Retinal dystrophy · score 0.19
- uric acid measurement · score 0.15
- blood metabolite measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWK6-F1 | alphafold | PREDICTED | 69.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWK6.
Amino-acid sequence (1321 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADGRA3?
The strongest Open Targets associations for ADGRA3 are adolescent idiopathic scoliosis, autosomal recessive retinitis pigmentosa, retinitis pigmentosa, PHF-tau measurement and urinary metabolite measurement.
How long is the ADGRA3 protein?
The Homo sapiens ADGRA3 protein (UniProt Q8IWK6) is 1321 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWK6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWK6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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