Pulmonary surfactant-associated protein A2 (SFTPA2)
Homo sapiens — UniProt Q8IWL1
Data last refreshed: (UniProt release unknown)
Key facts
Pulmonary surfactant-associated protein A2 (SFTPA2) is a protein from Homo sapiens identified by UniProt accession Q8IWL1, 248 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.
- UniProt accession: Q8IWL1; gene symbol SFTPA2.
- Organism: Homo sapiens.
- Length: 248 amino acids.
- Top disease associations (Open Targets): interstitial lung disease, idiopathic pulmonary fibrosis and newborn respiratory distress syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pulmonary surfactant-associated protein A2 |
|---|---|
| UniProt accession | Q8IWL1 |
| Gene | SFTPA2 |
| Organism | Homo sapiens |
| Length | 248 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (153)
Diseases linked to this target (Open Targets).
- interstitial lung disease · score 0.65
- idiopathic pulmonary fibrosis · score 0.63
- newborn respiratory distress syndrome · score 0.37
- body height · score 0.32
- grip strength measurement · score 0.28
- neurodegenerative disease · score 0.25
- cutaneous melanoma · score 0.24
- blood protein measurement · score 0.22
- genetic disorder · score 0.19
- FEV/FVC ratio · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWL1-F1 | alphafold | PREDICTED | 82.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWL1.
Amino-acid sequence (248 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SFTPA2?
The strongest Open Targets associations for SFTPA2 are interstitial lung disease, idiopathic pulmonary fibrosis, newborn respiratory distress syndrome, body height and grip strength measurement.
How long is the SFTPA2 protein?
The Homo sapiens SFTPA2 protein (UniProt Q8IWL1) is 248 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWL1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWL1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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