Pulmonary surfactant-associated protein A1 (SFTPA1)

About Pulmonary surfactant-associated protein A1

Pulmonary surfactant-associated protein A1 (SFTPA1) is a protein from Homo sapiens identified by UniProt accession Q8IWL2, 248 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Pulmonary surfactant-associated protein A1
UniProt accession	Q8IWL2
Gene	SFTPA1
Organism	Homo sapiens
Length	248 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

interstitial lung disease · score 0.58
newborn respiratory distress syndrome · score 0.37
respiratory distress syndrome in premature infants · score 0.37
neurodegenerative disease · score 0.28
cutaneous melanoma · score 0.24
blood protein measurement · score 0.16
head and neck squamous cell carcinoma · score 0.13
proximal 16p11.2 microdeletion syndrome · score 0.12
FEV/FVC ratio · score 0.10
squamous cell lung carcinoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWL2-F1	alphafold	PREDICTED	81.64	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWL2.

Amino-acid sequence (248 residues)

MWLCPLALNL ILMAASGAVC EVKDVCVGSP GIPGTPGSHG LPGRDGRDGL KGDPGPPGPM GPPGEMPCPP GNDGLPGAPG IPGECGEKGE PGERGPPGLP AHLDEELQAT LHDFRHQILQ TRGALSLQGS IMTVGEKVFS SNGQSITFDA IQEACARAGG RIAVPRNPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY SDGTPVNYTN WYRGEPAGRG KEQCVEMYTD GQWNDRNCLY SRLTICEF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards