Iron-sulfur cluster co-chaperone protein HscB (HSCB)
Homo sapiens — UniProt Q8IWL3
Data last refreshed: (UniProt release unknown)
Key facts
Iron-sulfur cluster co-chaperone protein HscB (HSCB) is a protein from Homo sapiens identified by UniProt accession Q8IWL3, 235 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q8IWL3; gene symbol HSCB.
- Organism: Homo sapiens.
- Length: 235 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Red cell distribution width and X-linked sideroblastic anemia 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Iron-sulfur cluster co-chaperone protein HscB |
|---|---|
| UniProt accession | Q8IWL3 |
| Gene | HSCB |
| Organism | Homo sapiens |
| Length | 235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Red cell distribution width · score 0.44
- X-linked sideroblastic anemia 1 · score 0.42
- mean corpuscular hemoglobin concentration · score 0.30
- lysosomal storage disease · score 0.27
- eosinophil count · score 0.15
- myeloproliferative disorder · score 0.11
- optic cup area measurement · score 0.10
- serum gamma-glutamyl transferase measurement · score 0.10
- serum alanine aminotransferase measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWL3-F1 | alphafold | PREDICTED | 83.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWL3.
Amino-acid sequence (235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HSCB?
The strongest Open Targets associations for HSCB are neurodegenerative disease, Red cell distribution width, X-linked sideroblastic anemia 1, mean corpuscular hemoglobin concentration and lysosomal storage disease.
How long is the HSCB protein?
The Homo sapiens HSCB protein (UniProt Q8IWL3) is 235 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWL3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWL3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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