Serine/threonine-protein kinase BRSK2 (BRSK2)
Homo sapiens — UniProt Q8IWQ3
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase BRSK2 (BRSK2) is a protein from Homo sapiens identified by UniProt accession Q8IWQ3, 736 residues long. MolForge cross-references it against 3 known binders and 86 disease associations.
- UniProt accession: Q8IWQ3; gene symbol BRSK2.
- Organism: Homo sapiens.
- Length: 736 amino acids.
- Top disease associations (Open Targets): genetic disorder, Neurodevelopmental disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase BRSK2 |
|---|---|
| UniProt accession | Q8IWQ3 |
| Gene | BRSK2 |
| Organism | Homo sapiens |
| Length | 736 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.51
- Neurodevelopmental disorder · score 0.49
- neurodegenerative disease · score 0.46
- Intellectual disability · score 0.40
- Autism · score 0.37
- Global developmental delay · score 0.37
- autism · score 0.37
- Atypical behavior · score 0.37
- autosomal dominant non-syndromic intellectual disability · score 0.37
- complex neurodevelopmental disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWQ3-F1 | alphafold | PREDICTED | 67.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWQ3.
Amino-acid sequence (736 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BRSK2?
The strongest Open Targets associations for BRSK2 are genetic disorder, Neurodevelopmental disorder, neurodegenerative disease, Intellectual disability and Autism.
How long is the BRSK2 protein?
The Homo sapiens BRSK2 protein (UniProt Q8IWQ3) is 736 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWQ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWQ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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