Sodium channel regulatory subunit beta-4 (SCN4B)
Homo sapiens — UniProt Q8IWT1
Data last refreshed: (UniProt release unknown)
Key facts
Sodium channel regulatory subunit beta-4 (SCN4B) is a protein from Homo sapiens identified by UniProt accession Q8IWT1, 228 residues long. MolForge cross-references it against 6 known binders and 185 disease associations.
- UniProt accession: Q8IWT1; gene symbol SCN4B.
- Organism: Homo sapiens.
- Length: 228 amino acids.
- Top disease associations (Open Targets): Romano-Ward syndrome, long QT syndrome 10 and atrial fibrillation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium channel regulatory subunit beta-4 |
|---|---|
| UniProt accession | Q8IWT1 |
| Gene | SCN4B |
| Organism | Homo sapiens |
| Length | 228 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (185)
Diseases linked to this target (Open Targets).
- Romano-Ward syndrome · score 0.62
- long QT syndrome 10 · score 0.61
- atrial fibrillation · score 0.51
- familial atrial fibrillation · score 0.51
- neurodegenerative disease · score 0.30
- familial long QT syndrome · score 0.20
- Abnormality of the cardiovascular system · score 0.19
- Prolonged QT interval · score 0.18
- sudden infant death syndrome · score 0.12
- dilated cardiomyopathy · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWT1-F1 | alphafold | PREDICTED | 83.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWT1.
Amino-acid sequence (228 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SCN4B?
The strongest Open Targets associations for SCN4B are Romano-Ward syndrome, long QT syndrome 10, atrial fibrillation, familial atrial fibrillation and neurodegenerative disease.
How long is the SCN4B protein?
The Homo sapiens SCN4B protein (UniProt Q8IWT1) is 228 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWT1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWT1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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