Sodium channel regulatory subunit beta-4 (SCN4B)

About Sodium channel regulatory subunit beta-4

Sodium channel regulatory subunit beta-4 (SCN4B) is a protein from Homo sapiens identified by UniProt accession Q8IWT1, 228 residues long. MolForge cross-references it against 0 known binders and 185 disease associations.

Target properties

Protein name	Sodium channel regulatory subunit beta-4
UniProt accession	Q8IWT1
Gene	SCN4B
Organism	Homo sapiens
Length	228 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (185)

Diseases linked to this target (Open Targets).

Romano-Ward syndrome · score 0.62
long QT syndrome 10 · score 0.61
atrial fibrillation · score 0.51
familial atrial fibrillation · score 0.51
neurodegenerative disease · score 0.30
familial long QT syndrome · score 0.20
Abnormality of the cardiovascular system · score 0.19
Prolonged QT interval · score 0.18
sudden infant death syndrome · score 0.12
dilated cardiomyopathy · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWT1-F1	alphafold	PREDICTED	83.05	—

Amino-acid sequence (228 residues)

MPGAGDGGKA PARWLGTGLL GLFLLPVTLS LEVSVGKATD IYAVNGTEIL LPCTFSSCFG FEDLHFRWTY NSSDAFKILI EGTVKNEKSD PKVTLKDDDR ITLVGSTKEK MNNISIVLRD LEFSDTGKYT CHVKNPKENN LQHHATIFLQ VVDRLEEVDN TVTLIILAVV GGVIGLLILI LLIKKLIIFI LKKTREKKKE CLVSSSGNDN TENGLPGSKA EEKPPSKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards