Proton-coupled zinc antiporter SLC30A8 (SLC30A8)
Homo sapiens — UniProt Q8IWU4
Data last refreshed: (UniProt release unknown)
Key facts
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) is a protein from Homo sapiens identified by UniProt accession Q8IWU4, 369 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.
- UniProt accession: Q8IWU4; gene symbol SLC30A8.
- Organism: Homo sapiens.
- Length: 369 amino acids.
- Top disease associations (Open Targets): HbA1c measurement, type 2 diabetes mellitus and glucose measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proton-coupled zinc antiporter SLC30A8 |
|---|---|
| UniProt accession | Q8IWU4 |
| Gene | SLC30A8 |
| Organism | Homo sapiens |
| Length | 369 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (115)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.66
- type 2 diabetes mellitus · score 0.62
- glucose measurement · score 0.48
- diabetes mellitus · score 0.47
- fasting blood glucose measurement · score 0.46
- triglyceride measurement · score 0.41
- BMI-adjusted fasting blood glucose measurement · score 0.40
- sex hormone-binding globulin measurement · score 0.40
- insulin measurement · score 0.40
- Drugs used in diabetes use measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWU4-F1 | alphafold | PREDICTED | 82.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWU4.
Amino-acid sequence (369 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC30A8?
The strongest Open Targets associations for SLC30A8 are HbA1c measurement, type 2 diabetes mellitus, glucose measurement, diabetes mellitus and fasting blood glucose measurement.
How long is the SLC30A8 protein?
The Homo sapiens SLC30A8 protein (UniProt Q8IWU4) is 369 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWU4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWU4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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