Extracellular sulfatase Sulf-2 (SULF2)
Homo sapiens — UniProt Q8IWU5
Data last refreshed: (UniProt release unknown)
Key facts
Extracellular sulfatase Sulf-2 (SULF2) is a protein from Homo sapiens identified by UniProt accession Q8IWU5, 870 residues long. MolForge cross-references it against 0 known binders and 192 disease associations.
- UniProt accession: Q8IWU5; gene symbol SULF2.
- Organism: Homo sapiens.
- Length: 870 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, body fat percentage and apolipoprotein A 1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Extracellular sulfatase Sulf-2 |
|---|---|
| UniProt accession | Q8IWU5 |
| Gene | SULF2 |
| Organism | Homo sapiens |
| Length | 870 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (192)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.52
- body fat percentage · score 0.50
- apolipoprotein A 1 measurement · score 0.48
- age at menarche · score 0.43
- cortical thickness · score 0.43
- fat body mass · score 0.42
- balding measurement · score 0.42
- cortical surface area measurement · score 0.42
- protein measurement · score 0.36
- brain measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWU5-F1 | alphafold | PREDICTED | 73.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWU5.
Amino-acid sequence (870 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SULF2?
The strongest Open Targets associations for SULF2 are high density lipoprotein cholesterol measurement, body fat percentage, apolipoprotein A 1 measurement, age at menarche and cortical thickness.
How long is the SULF2 protein?
The Homo sapiens SULF2 protein (UniProt Q8IWU5) is 870 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWU5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWU5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.