Tryptophan 5-hydroxylase 2 (TPH2)
Homo sapiens — UniProt Q8IWU9
Data last refreshed: (UniProt release unknown)
Key facts
Tryptophan 5-hydroxylase 2 (TPH2) is a protein from Homo sapiens identified by UniProt accession Q8IWU9, 490 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.
- UniProt accession: Q8IWU9; gene symbol TPH2.
- Organism: Homo sapiens.
- Length: 490 amino acids.
- Top disease associations (Open Targets): attention deficit hyperactivity disorder, neuroendocrine neoplasm and Diarrhea.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tryptophan 5-hydroxylase 2 |
|---|---|
| UniProt accession | Q8IWU9 |
| Gene | TPH2 |
| Organism | Homo sapiens |
| Length | 490 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (124)
Diseases linked to this target (Open Targets).
- attention deficit hyperactivity disorder · score 0.49
- neuroendocrine neoplasm · score 0.48
- Diarrhea · score 0.46
- carcinoid tumor · score 0.46
- unipolar depression · score 0.38
- carcinoid syndrome · score 0.36
- neurodegenerative disease · score 0.33
- large cell neuroendocrine carcinoma · score 0.26
- carcinoid heart disease · score 0.26
- small intestine neuroendocrine tumor, well differentiated, low or intermediate grade · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWU9-F1 | alphafold | PREDICTED | 83.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWU9.
Amino-acid sequence (490 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TPH2?
The strongest Open Targets associations for TPH2 are attention deficit hyperactivity disorder, neuroendocrine neoplasm, Diarrhea, carcinoid tumor and unipolar depression.
How long is the TPH2 protein?
The Homo sapiens TPH2 protein (UniProt Q8IWU9) is 490 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWU9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWU9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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