Lymphocyte transmembrane adapter 1 (LAX1)
Homo sapiens — UniProt Q8IWV1
Data last refreshed: (UniProt release unknown)
Key facts
Lymphocyte transmembrane adapter 1 (LAX1) is a protein from Homo sapiens identified by UniProt accession Q8IWV1, 398 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.
- UniProt accession: Q8IWV1; gene symbol LAX1.
- Organism: Homo sapiens.
- Length: 398 amino acids.
- Top disease associations (Open Targets): vertebral joint disease, appendicular lean mass and Chronic mucocutaneous candidosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lymphocyte transmembrane adapter 1 |
|---|---|
| UniProt accession | Q8IWV1 |
| Gene | LAX1 |
| Organism | Homo sapiens |
| Length | 398 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (161)
Diseases linked to this target (Open Targets).
- vertebral joint disease · score 0.08
- appendicular lean mass · score 0.07
- Chronic mucocutaneous candidosis · score 0.06
- hyper-IgM syndrome type 3 · score 0.06
- Hepatic veno-occlusive disease - immunodeficiency · score 0.06
- isolated agammaglobulinemia · score 0.06
- classic Hodgkin lymphoma · score 0.05
- Hodgkins lymphoma · score 0.05
- blood protein measurement · score 0.05
- common variable immunodeficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWV1-F1 | alphafold | PREDICTED | 48.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWV1.
Amino-acid sequence (398 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LAX1?
The strongest Open Targets associations for LAX1 are vertebral joint disease, appendicular lean mass, Chronic mucocutaneous candidosis, hyper-IgM syndrome type 3 and Hepatic veno-occlusive disease - immunodeficiency.
How long is the LAX1 protein?
The Homo sapiens LAX1 protein (UniProt Q8IWV1) is 398 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWV1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWV1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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