E3 ubiquitin-protein ligase UBR1 (UBR1)
Homo sapiens — UniProt Q8IWV7
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase UBR1 (UBR1) is a protein from Homo sapiens identified by UniProt accession Q8IWV7, 1749 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q8IWV7; gene symbol UBR1.
- Organism: Homo sapiens.
- Length: 1749 amino acids.
- Top disease associations (Open Targets): Johanson-Blizzard syndrome, genetic disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase UBR1 |
|---|---|
| UniProt accession | Q8IWV7 |
| Gene | UBR1 |
| Organism | Homo sapiens |
| Length | 1749 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- Johanson-Blizzard syndrome · score 0.82
- genetic disorder · score 0.47
- neurodegenerative disease · score 0.31
- body height · score 0.21
- clear cell renal carcinoma · score 0.18
- Microcephaly · score 0.14
- autism spectrum disorder · score 0.09
- bilirubin measurement · score 0.09
- triglyceride measurement · score 0.07
- hematocrit · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWV7-F1 | alphafold | PREDICTED | 84.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWV7.
Amino-acid sequence (1749 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBR1?
The strongest Open Targets associations for UBR1 are Johanson-Blizzard syndrome, genetic disorder, neurodegenerative disease, body height and clear cell renal carcinoma.
How long is the UBR1 protein?
The Homo sapiens UBR1 protein (UniProt Q8IWV7) is 1749 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWV7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWV7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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