E3 ubiquitin-protein ligase UBR2 (UBR2)
Homo sapiens — UniProt Q8IWV8
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase UBR2 (UBR2) is a protein from Homo sapiens identified by UniProt accession Q8IWV8, 1755 residues long. MolForge cross-references it against 0 known binders and 193 disease associations.
- UniProt accession: Q8IWV8; gene symbol UBR2.
- Organism: Homo sapiens.
- Length: 1755 amino acids.
- Top disease associations (Open Targets): body fat percentage, fat body mass and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase UBR2 |
|---|---|
| UniProt accession | Q8IWV8 |
| Gene | UBR2 |
| Organism | Homo sapiens |
| Length | 1755 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (193)
Diseases linked to this target (Open Targets).
- body fat percentage · score 0.33
- fat body mass · score 0.31
- eosinophil count · score 0.24
- neutrophil count · score 0.24
- body mass index · score 0.23
- leukocyte count · score 0.23
- eosinophil percentage of leukocytes · score 0.20
- neutrophil percentage of leukocytes · score 0.20
- clear cell renal carcinoma · score 0.18
- pancreatic adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWV8-F1 | alphafold | PREDICTED | 84.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWV8.
Amino-acid sequence (1755 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBR2?
The strongest Open Targets associations for UBR2 are body fat percentage, fat body mass, eosinophil count, neutrophil count and body mass index.
How long is the UBR2 protein?
The Homo sapiens UBR2 protein (UniProt Q8IWV8) is 1755 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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