Sphingosine-1-phosphate phosphatase 2 (SGPP2)
Homo sapiens — UniProt Q8IWX5
Data last refreshed: (UniProt release unknown)
Key facts
Sphingosine-1-phosphate phosphatase 2 (SGPP2) is a protein from Homo sapiens identified by UniProt accession Q8IWX5, 399 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q8IWX5; gene symbol SGPP2.
- Organism: Homo sapiens.
- Length: 399 amino acids.
- Top disease associations (Open Targets): facial morphology measurement, neurodegenerative disease and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingosine-1-phosphate phosphatase 2 |
|---|---|
| UniProt accession | Q8IWX5 |
| Gene | SGPP2 |
| Organism | Homo sapiens |
| Length | 399 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- facial morphology measurement · score 0.29
- neurodegenerative disease · score 0.25
- protein measurement · score 0.11
- autoimmune thyroid disease · score 0.07
- hair shape measurement · score 0.05
- age at first facial hair · score 0.05
- hyperinsulinemic hypoglycemia, familial, 2 · score 0.05
- exercise-induced hyperinsulinism · score 0.05
- hyperinsulinemic hypoglycemia, familial, 1 · score 0.04
- GCGR-related hyperglucagonemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWX5-F1 | alphafold | PREDICTED | 82.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWX5.
Amino-acid sequence (399 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SGPP2?
The strongest Open Targets associations for SGPP2 are facial morphology measurement, neurodegenerative disease, protein measurement, autoimmune thyroid disease and hair shape measurement.
How long is the SGPP2 protein?
The Homo sapiens SGPP2 protein (UniProt Q8IWX5) is 399 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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