Protein unc-45 homolog B (UNC45B)
Homo sapiens — UniProt Q8IWX7
Data last refreshed: (UniProt release unknown)
Key facts
Protein unc-45 homolog B (UNC45B) is a protein from Homo sapiens identified by UniProt accession Q8IWX7, 931 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q8IWX7; gene symbol UNC45B.
- Organism: Homo sapiens.
- Length: 931 amino acids.
- Top disease associations (Open Targets): myofibrillar myopathy 11, early-onset non-syndromic cataract and early-onset nuclear cataract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein unc-45 homolog B |
|---|---|
| UniProt accession | Q8IWX7 |
| Gene | UNC45B |
| Organism | Homo sapiens |
| Length | 931 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- myofibrillar myopathy 11 · score 0.67
- early-onset non-syndromic cataract · score 0.46
- early-onset nuclear cataract · score 0.37
- myopathy · score 0.33
- dilated cardiomyopathy 1A · score 0.26
- genetic disorder · score 0.19
- blood protein measurement · score 0.08
- sphingomyelin measurement · score 0.03
- cardiomyopathy · score 0.02
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWX7-F1 | alphafold | PREDICTED | 88.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWX7.
Amino-acid sequence (931 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UNC45B?
The strongest Open Targets associations for UNC45B are myofibrillar myopathy 11, early-onset non-syndromic cataract, early-onset nuclear cataract, myopathy and dilated cardiomyopathy 1A.
How long is the UNC45B protein?
The Homo sapiens UNC45B protein (UniProt Q8IWX7) is 931 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWX7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWX7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.