Calcium homeostasis endoplasmic reticulum protein (CHERP)
Homo sapiens — UniProt Q8IWX8
Data last refreshed: (UniProt release unknown)
Key facts
Calcium homeostasis endoplasmic reticulum protein (CHERP) is a protein from Homo sapiens identified by UniProt accession Q8IWX8, 916 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q8IWX8; gene symbol CHERP.
- Organism: Homo sapiens.
- Length: 916 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, genetic disorder and neuroblastoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium homeostasis endoplasmic reticulum protein |
|---|---|
| UniProt accession | Q8IWX8 |
| Gene | CHERP |
| Organism | Homo sapiens |
| Length | 916 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- genetic disorder · score 0.12
- neuroblastoma · score 0.07
- neutrophil percentage of granulocytes · score 0.07
- neutrophil-to-lymphocyte ratio · score 0.05
- self reported educational attainment · score 0.04
- eosinophil percentage of granulocytes · score 0.03
- lymphocyte count · score 0.03
- intelligence · score 0.03
- schizophrenia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWX8-F1 | alphafold | PREDICTED | 63.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWX8.
Amino-acid sequence (916 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHERP?
The strongest Open Targets associations for CHERP are neurodegenerative disease, genetic disorder, neuroblastoma, neutrophil percentage of granulocytes and neutrophil-to-lymphocyte ratio.
How long is the CHERP protein?
The Homo sapiens CHERP protein (UniProt Q8IWX8) is 916 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWX8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWX8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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