Signal peptide, CUB and EGF-like domain-containing protein 1 (SCUBE1)
Homo sapiens — UniProt Q8IWY4
Data last refreshed: (UniProt release unknown)
Key facts
Signal peptide, CUB and EGF-like domain-containing protein 1 (SCUBE1) is a protein from Homo sapiens identified by UniProt accession Q8IWY4, 988 residues long. MolForge cross-references it against 0 known binders and 197 disease associations.
- UniProt accession: Q8IWY4; gene symbol SCUBE1.
- Organism: Homo sapiens.
- Length: 988 amino acids.
- Top disease associations (Open Targets): blood protein measurement, appendicular lean mass and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal peptide, CUB and EGF-like domain-containing protein 1 |
|---|---|
| UniProt accession | Q8IWY4 |
| Gene | SCUBE1 |
| Organism | Homo sapiens |
| Length | 988 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (197)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.37
- appendicular lean mass · score 0.31
- body height · score 0.31
- neurodegenerative disease · score 0.21
- cortical thickness · score 0.11
- Von Willebrand disease · score 0.08
- pulmonary arterial hypertension · score 0.08
- hepatocellular carcinoma · score 0.07
- Glanzmann thrombasthenia 1 · score 0.07
- Rare hemorrhagic disorder due to a constitutional platelet anomaly · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWY4-F1 | alphafold | PREDICTED | 77.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWY4.
Amino-acid sequence (988 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SCUBE1?
The strongest Open Targets associations for SCUBE1 are blood protein measurement, appendicular lean mass, body height, neurodegenerative disease and cortical thickness.
How long is the SCUBE1 protein?
The Homo sapiens SCUBE1 protein (UniProt Q8IWY4) is 988 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWY4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWY4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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