E3 ubiquitin-protein ligase TRIM48 (TRIM48)
Homo sapiens — UniProt Q8IWZ4
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase TRIM48 (TRIM48) is a protein from Homo sapiens identified by UniProt accession Q8IWZ4, 224 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q8IWZ4; gene symbol TRIM48.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): acute myeloid leukemia, thyroid gland adenocarcinoma and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM48 |
|---|---|
| UniProt accession | Q8IWZ4 |
| Gene | TRIM48 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.20
- thyroid gland adenocarcinoma · score 0.18
- high density lipoprotein cholesterol measurement · score 0.18
- intraocular pressure measurement · score 0.17
- pappalysin‐1 measurement · score 0.16
- apolipoprotein A 1 measurement · score 0.14
- mean arterial pressure · score 0.14
- lymphocyte count · score 0.13
- red blood cell density measurement · score 0.13
- mean platelet volume · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWZ4-F1 | alphafold | PREDICTED | 81.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWZ4.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM48?
The strongest Open Targets associations for TRIM48 are acute myeloid leukemia, thyroid gland adenocarcinoma, high density lipoprotein cholesterol measurement, intraocular pressure measurement and pappalysin‐1 measurement.
How long is the TRIM48 protein?
The Homo sapiens TRIM48 protein (UniProt Q8IWZ4) is 224 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWZ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWZ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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