Tripartite motif-containing protein 42 (TRIM42)
Homo sapiens — UniProt Q8IWZ5
Data last refreshed: (UniProt release unknown)
Key facts
Tripartite motif-containing protein 42 (TRIM42) is a protein from Homo sapiens identified by UniProt accession Q8IWZ5, 723 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: Q8IWZ5; gene symbol TRIM42.
- Organism: Homo sapiens.
- Length: 723 amino acids.
- Top disease associations (Open Targets): protein measurement, adolescent idiopathic scoliosis and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tripartite motif-containing protein 42 |
|---|---|
| UniProt accession | Q8IWZ5 |
| Gene | TRIM42 |
| Organism | Homo sapiens |
| Length | 723 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.28
- adolescent idiopathic scoliosis · score 0.26
- neurodegenerative disease · score 0.21
- age-related hearing impairment · score 0.08
- acute myeloid leukemia · score 0.02
- graft versus host disease · score 0.01
- melanoma · score 0.01
- hepatitis C virus infection · score 0.00
- hepatocellular carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWZ5-F1 | alphafold | PREDICTED | 64.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWZ5.
Amino-acid sequence (723 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM42?
The strongest Open Targets associations for TRIM42 are protein measurement, adolescent idiopathic scoliosis, neurodegenerative disease, age-related hearing impairment and acute myeloid leukemia.
How long is the TRIM42 protein?
The Homo sapiens TRIM42 protein (UniProt Q8IWZ5) is 723 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWZ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWZ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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