BBSome complex member BBS7 (BBS7)
Homo sapiens — UniProt Q8IWZ6
Data last refreshed: (UniProt release unknown)
Key facts
BBSome complex member BBS7 (BBS7) is a protein from Homo sapiens identified by UniProt accession Q8IWZ6, 715 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.
- UniProt accession: Q8IWZ6; gene symbol BBS7.
- Organism: Homo sapiens.
- Length: 715 amino acids.
- Top disease associations (Open Targets): Bardet-Biedl syndrome 7, Bardet-Biedl syndrome and Bardet-Biedl syndrome 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BBSome complex member BBS7 |
|---|---|
| UniProt accession | Q8IWZ6 |
| Gene | BBS7 |
| Organism | Homo sapiens |
| Length | 715 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome 7 · score 0.81
- Bardet-Biedl syndrome · score 0.66
- Bardet-Biedl syndrome 1 · score 0.49
- Retinal dystrophy · score 0.47
- genetic disorder · score 0.47
- Polydactyly · score 0.46
- polydactyly · score 0.46
- retinitis pigmentosa · score 0.41
- Obesity · score 0.37
- ciliopathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWZ6-F1 | alphafold | PREDICTED | 92.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWZ6.
Amino-acid sequence (715 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BBS7?
The strongest Open Targets associations for BBS7 are Bardet-Biedl syndrome 7, Bardet-Biedl syndrome, Bardet-Biedl syndrome 1, Retinal dystrophy and genetic disorder.
How long is the BBS7 protein?
The Homo sapiens BBS7 protein (UniProt Q8IWZ6) is 715 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWZ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWZ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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