SURP and G-patch domain-containing protein 1 (SUGP1)
Homo sapiens — UniProt Q8IWZ8
Data last refreshed: (UniProt release unknown)
Key facts
SURP and G-patch domain-containing protein 1 (SUGP1) is a protein from Homo sapiens identified by UniProt accession Q8IWZ8, 645 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.
- UniProt accession: Q8IWZ8; gene symbol SUGP1.
- Organism: Homo sapiens.
- Length: 645 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, triglyceride measurement and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SURP and G-patch domain-containing protein 1 |
|---|---|
| UniProt accession | Q8IWZ8 |
| Gene | SUGP1 |
| Organism | Homo sapiens |
| Length | 645 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (174)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- triglyceride measurement · score 0.30
- total cholesterol measurement · score 0.30
- low density lipoprotein cholesterol measurement · score 0.28
- diabetes mellitus · score 0.20
- body mass index · score 0.20
- type 2 diabetes mellitus · score 0.17
- cortical surface area measurement · score 0.16
- bipolar disorder · score 0.15
- body height · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IWZ8-F1 | alphafold | PREDICTED | 64.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IWZ8.
Amino-acid sequence (645 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SUGP1?
The strongest Open Targets associations for SUGP1 are neurodegenerative disease, triglyceride measurement, total cholesterol measurement, low density lipoprotein cholesterol measurement and diabetes mellitus.
How long is the SUGP1 protein?
The Homo sapiens SUGP1 protein (UniProt Q8IWZ8) is 645 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IWZ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IWZ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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