Transmembrane protein 183A (TMEM183A)
Homo sapiens — UniProt Q8IXX5
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 183A (TMEM183A) is a protein from Homo sapiens identified by UniProt accession Q8IXX5, 376 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.
- UniProt accession: Q8IXX5; gene symbol TMEM183A.
- Organism: Homo sapiens.
- Length: 376 amino acids.
- Top disease associations (Open Targets): prostate carcinoma, prostate cancer and Familial prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 183A |
|---|---|
| UniProt accession | Q8IXX5 |
| Gene | TMEM183A |
| Organism | Homo sapiens |
| Length | 376 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (7)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- acute lymphoblastic leukemia · score 0.00
- Alzheimer disease · score 0.00
- astrocytoma · score 0.00
- hepatocellular carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IXX5-F1 | alphafold | PREDICTED | 72.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IXX5.
Amino-acid sequence (376 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM183A?
The strongest Open Targets associations for TMEM183A are prostate carcinoma, prostate cancer, Familial prostate cancer, acute lymphoblastic leukemia and Alzheimer disease.
How long is the TMEM183A protein?
The Homo sapiens TMEM183A protein (UniProt Q8IXX5) is 376 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IXX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IXX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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