Patatin-like phospholipase domain-containing protein 6 (PNPLA6)
Homo sapiens — UniProt Q8IY17
Data last refreshed: (UniProt release unknown)
Key facts
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) is a protein from Homo sapiens identified by UniProt accession Q8IY17, 1375 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.
- UniProt accession: Q8IY17; gene symbol PNPLA6.
- Organism: Homo sapiens.
- Length: 1375 amino acids.
- Top disease associations (Open Targets): ataxia-hypogonadism-choroidal dystrophy syndrome, Autosomal recessive spastic paraplegia type 39 and hereditary spastic paraplegia 39.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Patatin-like phospholipase domain-containing protein 6 |
|---|---|
| UniProt accession | Q8IY17 |
| Gene | PNPLA6 |
| Organism | Homo sapiens |
| Length | 1375 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (121)
Diseases linked to this target (Open Targets).
- ataxia-hypogonadism-choroidal dystrophy syndrome · score 0.83
- Autosomal recessive spastic paraplegia type 39 · score 0.81
- hereditary spastic paraplegia 39 · score 0.79
- Ataxia - hypogonadism - choroidal dystrophy · score 0.79
- trichomegaly-retina pigmentary degeneration-dwarfism syndrome · score 0.78
- Trichomegaly - retina pigmentary degeneration - dwarfism · score 0.75
- Laurence-Moon syndrome · score 0.62
- hereditary spastic paraplegia · score 0.47
- spastic ataxia · score 0.47
- genetic disorder · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY17-F1 | alphafold | PREDICTED | 69.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY17.
Amino-acid sequence (1375 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PNPLA6?
The strongest Open Targets associations for PNPLA6 are ataxia-hypogonadism-choroidal dystrophy syndrome, Autosomal recessive spastic paraplegia type 39, hereditary spastic paraplegia 39, Ataxia - hypogonadism - choroidal dystrophy and trichomegaly-retina pigmentary degeneration-dwarfism syndrome.
How long is the PNPLA6 protein?
The Homo sapiens PNPLA6 protein (UniProt Q8IY17) is 1375 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY17 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY17 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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