Structural maintenance of chromosomes protein 5 (SMC5)
Homo sapiens — UniProt Q8IY18
Data last refreshed: (UniProt release unknown)
Key facts
Structural maintenance of chromosomes protein 5 (SMC5) is a protein from Homo sapiens identified by UniProt accession Q8IY18, 1101 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.
- UniProt accession: Q8IY18; gene symbol SMC5.
- Organism: Homo sapiens.
- Length: 1101 amino acids.
- Top disease associations (Open Targets): Atelis syndrome 2, ovarian cancer and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Structural maintenance of chromosomes protein 5 |
|---|---|
| UniProt accession | Q8IY18 |
| Gene | SMC5 |
| Organism | Homo sapiens |
| Length | 1101 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (143)
Diseases linked to this target (Open Targets).
- Atelis syndrome 2 · score 0.55
- ovarian cancer · score 0.23
- endometrial cancer · score 0.23
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.20
- genetic disorder · score 0.19
- neurodegenerative disease · score 0.19
- acute myeloid leukemia · score 0.15
- esophageal cancer · score 0.14
- ulcerative colitis · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY18-F1 | alphafold | PREDICTED | 79.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY18.
Amino-acid sequence (1101 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMC5?
The strongest Open Targets associations for SMC5 are Atelis syndrome 2, ovarian cancer, endometrial cancer, breast adenocarcinoma and glioblastoma multiforme.
How long is the SMC5 protein?
The Homo sapiens SMC5 protein (UniProt Q8IY18) is 1101 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY18 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY18 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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