Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6)
Homo sapiens — UniProt Q8IY26
Data last refreshed: (UniProt release unknown)
Key facts
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) is a protein from Homo sapiens identified by UniProt accession Q8IY26, 295 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q8IY26; gene symbol PLPP6.
- Organism: Homo sapiens.
- Length: 295 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, erythrocyte count and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 |
|---|---|
| UniProt accession | Q8IY26 |
| Gene | PLPP6 |
| Organism | Homo sapiens |
| Length | 295 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.34
- erythrocyte count · score 0.27
- platelet crit · score 0.23
- neutrophil count · score 0.19
- mean platelet volume · score 0.19
- mean corpuscular hemoglobin · score 0.19
- mean corpuscular hemoglobin concentration · score 0.17
- red blood cell density measurement · score 0.17
- platelet count · score 0.12
- leukocyte count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY26-F1 | alphafold | PREDICTED | 72.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY26.
Amino-acid sequence (295 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLPP6?
The strongest Open Targets associations for PLPP6 are mean corpuscular volume, erythrocyte count, platelet crit, neutrophil count and mean platelet volume.
How long is the PLPP6 protein?
The Homo sapiens PLPP6 protein (UniProt Q8IY26) is 295 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY26 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY26 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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