Solute carrier family 15 member 3 (SLC15A3)
Homo sapiens — UniProt Q8IY34
Data last refreshed: (UniProt release unknown)
Key facts
Solute carrier family 15 member 3 (SLC15A3) is a protein from Homo sapiens identified by UniProt accession Q8IY34, 581 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q8IY34; gene symbol SLC15A3.
- Organism: Homo sapiens.
- Length: 581 amino acids.
- Top disease associations (Open Targets): cathepsin L1 measurement, inflammatory bowel disease and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Solute carrier family 15 member 3 |
|---|---|
| UniProt accession | Q8IY34 |
| Gene | SLC15A3 |
| Organism | Homo sapiens |
| Length | 581 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- cathepsin L1 measurement · score 0.25
- inflammatory bowel disease · score 0.14
- cutaneous melanoma · score 0.13
- type 1 diabetes mellitus · score 0.11
- lymphocyte count · score 0.08
- Blackfan-Diamond anemia · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- neutropenia, severe congenital, 2, autosomal dominant · score 0.05
- IRIDA syndrome · score 0.05
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY34-F1 | alphafold | PREDICTED | 80.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY34.
Amino-acid sequence (581 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC15A3?
The strongest Open Targets associations for SLC15A3 are cathepsin L1 measurement, inflammatory bowel disease, cutaneous melanoma, type 1 diabetes mellitus and lymphocyte count.
How long is the SLC15A3 protein?
The Homo sapiens SLC15A3 protein (UniProt Q8IY34) is 581 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY34 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY34 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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