PDCD10 and GCKIII kinases-associated protein 1 (PGCKA1)
Homo sapiens — UniProt Q8IY42
Data last refreshed: (UniProt release unknown)
Key facts
PDCD10 and GCKIII kinases-associated protein 1 (PGCKA1) is a protein from Homo sapiens identified by UniProt accession Q8IY42, 314 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q8IY42; gene symbol PGCKA1.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): serum gamma-glutamyl transferase measurement, serum alanine aminotransferase measurement and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PDCD10 and GCKIII kinases-associated protein 1 |
|---|---|
| UniProt accession | Q8IY42 |
| Gene | PGCKA1 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.43
- serum alanine aminotransferase measurement · score 0.38
- cutaneous melanoma · score 0.33
- nevus count · score 0.33
- adolescent idiopathic scoliosis · score 0.33
- substance abuse · score 0.27
- alkaline phosphatase measurement · score 0.22
- neurodegenerative disease · score 0.17
- sex hormone-binding globulin measurement · score 0.11
- familial apolipoprotein C-II deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY42-F1 | alphafold | PREDICTED | 54.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY42.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PGCKA1?
The strongest Open Targets associations for PGCKA1 are serum gamma-glutamyl transferase measurement, serum alanine aminotransferase measurement, cutaneous melanoma, nevus count and adolescent idiopathic scoliosis.
How long is the PGCKA1 protein?
The Homo sapiens PGCKA1 protein (UniProt Q8IY42) is 314 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY42 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY42 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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