Monocyte to macrophage differentiation factor 2 (MMD2)
Homo sapiens — UniProt Q8IY49
Data last refreshed: (UniProt release unknown)
Key facts
Monocyte to macrophage differentiation factor 2 (MMD2) is a protein from Homo sapiens identified by UniProt accession Q8IY49, 270 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q8IY49; gene symbol MMD2.
- Organism: Homo sapiens.
- Length: 270 amino acids.
- Top disease associations (Open Targets): DNA methylation, Down syndrome and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Monocyte to macrophage differentiation factor 2 |
|---|---|
| UniProt accession | Q8IY49 |
| Gene | MMD2 |
| Organism | Homo sapiens |
| Length | 270 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- DNA methylation · score 0.25
- Down syndrome · score 0.03
- breast carcinoma · score 0.02
- neutropenia · score 0.01
- non-alcoholic steatohepatitis · score 0.00
- cancer · score 0.00
- endometriosis · score 0.00
- periodontitis · score 0.00
- neoplasm · score 0.00
- gonorrhea · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY49-F1 | alphafold | PREDICTED | 87.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY49.
Amino-acid sequence (270 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MMD2?
The strongest Open Targets associations for MMD2 are DNA methylation, Down syndrome, breast carcinoma, neutropenia and non-alcoholic steatohepatitis.
How long is the MMD2 protein?
The Homo sapiens MMD2 protein (UniProt Q8IY49) is 270 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY49 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY49 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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