Tigger transposable element-derived protein 4 (TIGD4)
Homo sapiens — UniProt Q8IY51
Data last refreshed: (UniProt release unknown)
Key facts
Tigger transposable element-derived protein 4 (TIGD4) is a protein from Homo sapiens identified by UniProt accession Q8IY51, 512 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q8IY51; gene symbol TIGD4.
- Organism: Homo sapiens.
- Length: 512 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, reticulocyte count and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tigger transposable element-derived protein 4 |
|---|---|
| UniProt accession | Q8IY51 |
| Gene | TIGD4 |
| Organism | Homo sapiens |
| Length | 512 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.34
- reticulocyte count · score 0.30
- FEV/FVC ratio · score 0.27
- mean corpuscular hemoglobin concentration · score 0.17
- reticulocyte measurement · score 0.17
- mean platelet volume · score 0.16
- mean corpuscular volume · score 0.15
- HbA1c measurement · score 0.15
- type 2 diabetes mellitus · score 0.02
- protein measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY51-F1 | alphafold | PREDICTED | 78.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY51.
Amino-acid sequence (512 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TIGD4?
The strongest Open Targets associations for TIGD4 are Red cell distribution width, reticulocyte count, FEV/FVC ratio, mean corpuscular hemoglobin concentration and reticulocyte measurement.
How long is the TIGD4 protein?
The Homo sapiens TIGD4 protein (UniProt Q8IY51) is 512 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY51 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY51 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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