YY1-associated factor 2 (YAF2)
Homo sapiens — UniProt Q8IY57
Data last refreshed: (UniProt release unknown)
Key facts
YY1-associated factor 2 (YAF2) is a protein from Homo sapiens identified by UniProt accession Q8IY57, 180 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8IY57; gene symbol YAF2.
- Organism: Homo sapiens.
- Length: 180 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, urate measurement and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | YY1-associated factor 2 |
|---|---|
| UniProt accession | Q8IY57 |
| Gene | YAF2 |
| Organism | Homo sapiens |
| Length | 180 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.17
- urate measurement · score 0.10
- appendicular lean mass · score 0.08
- non-small cell lung carcinoma · score 0.06
- refractive error · score 0.05
- blood urea nitrogen measurement · score 0.05
- colorectal cancer · score 0.04
- response to sulfonylurea · score 0.03
- HbA1c measurement · score 0.03
- carpal tunnel syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY57-F1 | alphafold | PREDICTED | 67.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY57.
Amino-acid sequence (180 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with YAF2?
The strongest Open Targets associations for YAF2 are diastolic blood pressure, urate measurement, appendicular lean mass, non-small cell lung carcinoma and refractive error.
How long is the YAF2 protein?
The Homo sapiens YAF2 protein (UniProt Q8IY57) is 180 amino acids long.
Browse: Targets: Y · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY57 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY57 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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