pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (FTSJ3)
Homo sapiens — UniProt Q8IY81
Data last refreshed: (UniProt release unknown)
Key facts
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (FTSJ3) is a protein from Homo sapiens identified by UniProt accession Q8IY81, 847 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q8IY81; gene symbol FTSJ3.
- Organism: Homo sapiens.
- Length: 847 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, erythrocyte count and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 |
|---|---|
| UniProt accession | Q8IY81 |
| Gene | FTSJ3 |
| Organism | Homo sapiens |
| Length | 847 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- erythrocyte count · score 0.23
- leukocyte count · score 0.22
- hematocrit · score 0.18
- hemoglobin measurement · score 0.18
- myeloid white cell count · score 0.13
- mean corpuscular hemoglobin concentration · score 0.13
- body height · score 0.12
- mean platelet volume · score 0.12
- mathematical ability · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY81-F1 | alphafold | PREDICTED | 70.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY81.
Amino-acid sequence (847 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FTSJ3?
The strongest Open Targets associations for FTSJ3 are neurodegenerative disease, erythrocyte count, leukocyte count, hematocrit and hemoglobin measurement.
How long is the FTSJ3 protein?
The Homo sapiens FTSJ3 protein (UniProt Q8IY81) is 847 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY81 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY81 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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