Dynein regulatory complex subunit 7 (DRC7)
Homo sapiens — UniProt Q8IY82
Data last refreshed: (UniProt release unknown)
Key facts
Dynein regulatory complex subunit 7 (DRC7) is a protein from Homo sapiens identified by UniProt accession Q8IY82, 874 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.
- UniProt accession: Q8IY82; gene symbol DRC7.
- Organism: Homo sapiens.
- Length: 874 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein regulatory complex subunit 7 |
|---|---|
| UniProt accession | Q8IY82 |
| Gene | DRC7 |
| Organism | Homo sapiens |
| Length | 874 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (134)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- metabolite measurement · score 0.08
- spermatogenic failure 65 · score 0.08
- spermatogenic failure 56 · score 0.08
- spermatogenic failure, X-linked, 3 · score 0.08
- spermatogenic failure 10 · score 0.08
- spermatogenic failure 11 · score 0.08
- spermatogenic failure 40 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IY82-F1 | alphafold | PREDICTED | 82.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IY82.
Amino-acid sequence (874 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DRC7?
The strongest Open Targets associations for DRC7 are azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion, metabolite measurement and spermatogenic failure 65.
How long is the DRC7 protein?
The Homo sapiens DRC7 protein (UniProt Q8IY82) is 874 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IY82 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IY82 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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