Nucleotidyltransferase MB21D2 (MB21D2)
Homo sapiens — UniProt Q8IYB1
Data last refreshed: (UniProt release unknown)
Key facts
Nucleotidyltransferase MB21D2 (MB21D2) is a protein from Homo sapiens identified by UniProt accession Q8IYB1, 491 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q8IYB1; gene symbol MB21D2.
- Organism: Homo sapiens.
- Length: 491 amino acids.
- Top disease associations (Open Targets): thyroid disease, brain volume measurement and hypothyroidism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleotidyltransferase MB21D2 |
|---|---|
| UniProt accession | Q8IYB1 |
| Gene | MB21D2 |
| Organism | Homo sapiens |
| Length | 491 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- thyroid disease · score 0.29
- brain volume measurement · score 0.29
- hypothyroidism · score 0.29
- Herpes Zoster · score 0.26
- daytime rest measurement · score 0.26
- lung adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.25
- squamous cell lung carcinoma · score 0.22
- carcinoma of liver and intrahepatic biliary tract · score 0.19
- oral squamous cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYB1-F1 | alphafold | PREDICTED | 83.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYB1.
Amino-acid sequence (491 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MB21D2?
The strongest Open Targets associations for MB21D2 are thyroid disease, brain volume measurement, hypothyroidism, Herpes Zoster and daytime rest measurement.
How long is the MB21D2 protein?
The Homo sapiens MB21D2 protein (UniProt Q8IYB1) is 491 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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