PEX5-related protein (PEX5L)
Homo sapiens — UniProt Q8IYB4
Data last refreshed: (UniProt release unknown)
Key facts
PEX5-related protein (PEX5L) is a protein from Homo sapiens identified by UniProt accession Q8IYB4, 626 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q8IYB4; gene symbol PEX5L.
- Organism: Homo sapiens.
- Length: 626 amino acids.
- Top disease associations (Open Targets): blood metabolite measurement, PHF-tau measurement and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PEX5-related protein |
|---|---|
| UniProt accession | Q8IYB4 |
| Gene | PEX5L |
| Organism | Homo sapiens |
| Length | 626 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- blood metabolite measurement · score 0.32
- PHF-tau measurement · score 0.31
- neurodegenerative disease · score 0.28
- adolescent idiopathic scoliosis · score 0.11
- ependymoma · score 0.04
- childhood disintegrative disorder · score 0.04
- glioblastoma multiforme · score 0.03
- astrocytoma · score 0.02
- oligodendroglioma · score 0.02
- temporal lobe epilepsy · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYB4-F1 | alphafold | PREDICTED | 63.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYB4.
Amino-acid sequence (626 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PEX5L?
The strongest Open Targets associations for PEX5L are blood metabolite measurement, PHF-tau measurement, neurodegenerative disease, adolescent idiopathic scoliosis and ependymoma.
How long is the PEX5L protein?
The Homo sapiens PEX5L protein (UniProt Q8IYB4) is 626 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYB4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYB4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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