Stromal membrane-associated protein 1 (SMAP1)
Homo sapiens — UniProt Q8IYB5
Data last refreshed: (UniProt release unknown)
Key facts
Stromal membrane-associated protein 1 (SMAP1) is a protein from Homo sapiens identified by UniProt accession Q8IYB5, 467 residues long. MolForge cross-references it against 0 known binders and 315 disease associations.
- UniProt accession: Q8IYB5; gene symbol SMAP1.
- Organism: Homo sapiens.
- Length: 467 amino acids.
- Top disease associations (Open Targets): mean platelet volume, metabolite measurement and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Stromal membrane-associated protein 1 |
|---|---|
| UniProt accession | Q8IYB5 |
| Gene | SMAP1 |
| Organism | Homo sapiens |
| Length | 467 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (315)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.27
- metabolite measurement · score 0.26
- platelet component distribution width · score 0.24
- Blackfan-Diamond anemia · score 0.07
- myelodysplastic syndrome associated with isolated del(5q) · score 0.06
- X-linked sideroblastic anemia 1 · score 0.06
- alpha-thalassemia-myelodysplastic syndrome · score 0.06
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.06
- refractory anemia · score 0.06
- Familial hemophagocytic lymphohistiocytosis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYB5-F1 | alphafold | PREDICTED | 60.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYB5.
Amino-acid sequence (467 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAP1?
The strongest Open Targets associations for SMAP1 are mean platelet volume, metabolite measurement, platelet component distribution width, Blackfan-Diamond anemia and myelodysplastic syndrome associated with isolated del(5q).
How long is the SMAP1 protein?
The Homo sapiens SMAP1 protein (UniProt Q8IYB5) is 467 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYB5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYB5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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