DIS3-like exonuclease 2 (DIS3L2)
Homo sapiens — UniProt Q8IYB7
Data last refreshed: (UniProt release unknown)
Key facts
DIS3-like exonuclease 2 (DIS3L2) is a protein from Homo sapiens identified by UniProt accession Q8IYB7, 885 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q8IYB7; gene symbol DIS3L2.
- Organism: Homo sapiens.
- Length: 885 amino acids.
- Top disease associations (Open Targets): Perlman syndrome, body height and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DIS3-like exonuclease 2 |
|---|---|
| UniProt accession | Q8IYB7 |
| Gene | DIS3L2 |
| Organism | Homo sapiens |
| Length | 885 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- Perlman syndrome · score 0.81
- body height · score 0.47
- appendicular lean mass · score 0.40
- BMI-adjusted waist circumference · score 0.40
- forced expiratory volume · score 0.37
- vital capacity · score 0.36
- lean body mass · score 0.35
- sitting height measurement · score 0.34
- BMI-adjusted hip circumference · score 0.32
- physical activity measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYB7-F1 | alphafold | PREDICTED | 82.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYB7.
Amino-acid sequence (885 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DIS3L2?
The strongest Open Targets associations for DIS3L2 are Perlman syndrome, body height, appendicular lean mass, BMI-adjusted waist circumference and forced expiratory volume.
How long is the DIS3L2 protein?
The Homo sapiens DIS3L2 protein (UniProt Q8IYB7) is 885 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYB7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYB7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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