ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1)
Homo sapiens — UniProt Q8IYB8
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) is a protein from Homo sapiens identified by UniProt accession Q8IYB8, 786 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q8IYB8; gene symbol SUPV3L1.
- Organism: Homo sapiens.
- Length: 786 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, type 2 diabetes mellitus and cytokine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent RNA helicase SUPV3L1, mitochondrial |
|---|---|
| UniProt accession | Q8IYB8 |
| Gene | SUPV3L1 |
| Organism | Homo sapiens |
| Length | 786 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- type 2 diabetes mellitus · score 0.26
- cytokine measurement · score 0.16
- response to vaccine · score 0.16
- basophil count · score 0.10
- lymphocyte count · score 0.09
- basophil percentage of leukocytes · score 0.08
- birth weight · score 0.06
- lymphocyte percentage of leukocytes · score 0.06
- serum alanine aminotransferase measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYB8-F1 | alphafold | PREDICTED | 83.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYB8.
Amino-acid sequence (786 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SUPV3L1?
The strongest Open Targets associations for SUPV3L1 are neurodegenerative disease, type 2 diabetes mellitus, cytokine measurement, response to vaccine and basophil count.
How long is the SUPV3L1 protein?
The Homo sapiens SUPV3L1 protein (UniProt Q8IYB8) is 786 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYB8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYB8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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