Zinc finger protein 595 (ZNF595)
Homo sapiens — UniProt Q8IYB9
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 595 (ZNF595) is a protein from Homo sapiens identified by UniProt accession Q8IYB9, 648 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q8IYB9; gene symbol ZNF595.
- Organism: Homo sapiens.
- Length: 648 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Blackfan-Diamond anemia and X-linked severe congenital neutropenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 595 |
|---|---|
| UniProt accession | Q8IYB9 |
| Gene | ZNF595 |
| Organism | Homo sapiens |
| Length | 648 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- Blackfan-Diamond anemia · score 0.05
- X-linked severe congenital neutropenia · score 0.04
- neutropenia, severe congenital, 2, autosomal dominant · score 0.04
- Ataxia-telangiectasia · score 0.04
- nonimmune chronic idiopathic neutropenia of adults · score 0.04
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency · score 0.04
- reticular dysgenesis · score 0.04
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
- combined immunodeficiency with skin granulomas · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYB9-F1 | alphafold | PREDICTED | 76.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYB9.
Amino-acid sequence (648 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF595?
The strongest Open Targets associations for ZNF595 are neurodegenerative disease, Blackfan-Diamond anemia, X-linked severe congenital neutropenia, neutropenia, severe congenital, 2, autosomal dominant and Ataxia-telangiectasia.
How long is the ZNF595 protein?
The Homo sapiens ZNF595 protein (UniProt Q8IYB9) is 648 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYB9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYB9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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