Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)
Homo sapiens — UniProt Q8IYD1
Data last refreshed: (UniProt release unknown)
Key facts
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2) is a protein from Homo sapiens identified by UniProt accession Q8IYD1, 628 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q8IYD1; gene symbol GSPT2.
- Organism: Homo sapiens.
- Length: 628 amino acids.
- Top disease associations (Open Targets): autism, Seizure and Delayed speech and language development.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B |
|---|---|
| UniProt accession | Q8IYD1 |
| Gene | GSPT2 |
| Organism | Homo sapiens |
| Length | 628 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- autism · score 0.33
- Seizure · score 0.33
- Delayed speech and language development · score 0.33
- endometrial cancer · score 0.25
- glioblastoma multiforme · score 0.10
- Gorham-Stout disease · score 0.07
- melorheostosis · score 0.05
- hepatocellular carcinoma · score 0.04
- chronic hepatitis B virus infection · score 0.03
- laryngotracheoesophageal cleft · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYD1-F1 | alphafold | PREDICTED | 74.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYD1.
Amino-acid sequence (628 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GSPT2?
The strongest Open Targets associations for GSPT2 are autism, Seizure, Delayed speech and language development, endometrial cancer and glioblastoma multiforme.
How long is the GSPT2 protein?
The Homo sapiens GSPT2 protein (UniProt Q8IYD1) is 628 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYD1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYD1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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